Famotidine and Omeprazole Both Induce Gastric Transmucosal Leak
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منابع مشابه
Famotidine and Omeprazole Both Induce Gastric Transmucosal Leak
Background: Our group has recently published that proton pump inhibitors (PPIs) induce transmucosal, paracellular, bidirectional leakage in the gastric corpus epithelium to a wide range of molecules. Aim: This study was undertaken to determine if H-2 blocker medications also induce such leakage, or whether it is a result of specific inhibition of H + ,K + -ATPase. Methods: At the beginning and ...
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BACKGROUND Although proton pump inhibitors (PPI) and H2-receptor antagonists (H2-RA) are routinely used in the treatment of reflux esophagitis (RE), no consensus has been reached yet as to whether the first-choice drug should be PPI or H2-RA. In this study, the effects of omeprazole (OMP) and famotidine (FAM) on RE have been examined in a randomized comparative study. METHODS Protocols of OMP...
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Objective: To study whether the increasing doses of omeprazole, lansoprazole and famotidine afford protection against ethanol-induced gastric damage and to compare their antioxidant effect with that of melatonin. Material and Methods: Mucosal damage was evaluated by macroscopic examination and by the measurement of lipid peroxidation (LPO), glutathione (GSH) levels and myeloperoxidase (MPO) act...
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BACKGROUND In Japan, treatment guidelines are lacking for patients with upper gastrointestinal symptoms. We aimed to compare the efficacy of different drugs for the treatment of uninvestigated upper gastrointestinal symptoms. METHODS This was a randomized, open-label, parallel-group multicenter study. Helicobacter pylori-negative, endoscopically uninvestigated patients ≥ 20 years of age with ...
متن کاملSerum Concentrations of Gastrin after Famotidine and Omeprazole Administration to Dogs
BACKGROUND The duration of antacid-induced hypergastrinemia after cessation of administration of omeprazole and famotidine apparently has not been determined in dogs. HYPOTHESIS That serum gastrin will return to basal concentrations by 7 days after cessation of famotidine or omeprazole administration. ANIMALS Nine healthy, adult, male, research colony dogs. METHODS Randomized, cross-over ...
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ژورنال
عنوان ژورنال: Journal of Epithelial Biology and Pharmacology
سال: 2011
ISSN: 1875-0443
DOI: 10.2174/1875044301104010007